Pure red cell aplasia (PRCA) is increasingly recognised as a T-cell-mediated bone marrow failure syndrome, yet its immunogenetic drivers remain poorly defined. In their paper, Yamashita et al. integrate human leucocyte antigen (HLA) typing, T-cell receptor repertoire analysis and mutational profiling to reveal enriched HLA alleles, signal transducer and activator of transcription 3 (STAT3)-mutated T-cell clones and a shared T cell receptor beta (TCR beta) motif in PRCA patients. These findings suggest that antigen-driven cytotoxic T-cell responses represent a central mechanism underlying erythroid suppression. Commentary on: Yamashita et al. Immunological features of acquired PRCA: Specific HLA alleles, STAT3 mutations and a unique TCR beta motif. Br J Haematol 2026 (Online ahead of print). doi: 10.1111/bjh.70475.
Decoding immune-driven erythroid failure in pure red cell aplasia
Spataro F.;Desantis V.;Solimando A. G.
2026-01-01
Abstract
Pure red cell aplasia (PRCA) is increasingly recognised as a T-cell-mediated bone marrow failure syndrome, yet its immunogenetic drivers remain poorly defined. In their paper, Yamashita et al. integrate human leucocyte antigen (HLA) typing, T-cell receptor repertoire analysis and mutational profiling to reveal enriched HLA alleles, signal transducer and activator of transcription 3 (STAT3)-mutated T-cell clones and a shared T cell receptor beta (TCR beta) motif in PRCA patients. These findings suggest that antigen-driven cytotoxic T-cell responses represent a central mechanism underlying erythroid suppression. Commentary on: Yamashita et al. Immunological features of acquired PRCA: Specific HLA alleles, STAT3 mutations and a unique TCR beta motif. Br J Haematol 2026 (Online ahead of print). doi: 10.1111/bjh.70475.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
