Use of Pentoxifylline to Improve Seminal Parameters in Dogs

Objective The study aimed to evaluate the effect of a one-shot oral administration of pentoxifylline on semen parameters in normospermic and oligospermic dogs. Methods Twenty-nine dogs were categorized as normospermic or oligospermic based on baseline sperm concentration. After 10 days from the first semen evaluation, each dog received 10 mg/kg of pentoxifylline orally, given 40 min prior to ejaculation. Semen was evaluated using a Computer-Assisted Sperm Analysis (CASA) system and Eosin-Nigrosin staining for vitality. Results Compared with baseline, pentoxifylline treatment resulted in a statistically significant increase in sperm concentration and progressive motility (p < 0.01), most notably in oligospermic dogs. Conclusion and Clinical Significance These findings highlight the beneficial effects of pentoxifylline and confirm its potential as an adjunct therapy for improving semen quality in subfertile male dogs.