In this work several nanoporous titania powders have been considered as potential carriers for the sustained release of ibuprofen, used as model drug. The textural features and the physico-chemical nature of the surface carriers have been investigated by means of N2physisorption measurements and FT-IR analyses. The delivery profiles have been collected in vitro in physiological solution at pH 7.4, maintaining the temperature at 37 °C. It has been possible to observe a close correlation between the drug release kinetic and the textural properties of the carriers, in particular for what concerns their pores dimension. The choice of the proper synthetic approach allows a high control of the properties of the final material and of its behaviour in the drug delivery process that can be controlled to a very high extent. © 2010 Elsevier Inc. All rights reserved.
Effect of textural properties on the drug delivery behaviour of nanoporous TiO2matrices
Ghedini E.;
2011-01-01
Abstract
In this work several nanoporous titania powders have been considered as potential carriers for the sustained release of ibuprofen, used as model drug. The textural features and the physico-chemical nature of the surface carriers have been investigated by means of N2physisorption measurements and FT-IR analyses. The delivery profiles have been collected in vitro in physiological solution at pH 7.4, maintaining the temperature at 37 °C. It has been possible to observe a close correlation between the drug release kinetic and the textural properties of the carriers, in particular for what concerns their pores dimension. The choice of the proper synthetic approach allows a high control of the properties of the final material and of its behaviour in the drug delivery process that can be controlled to a very high extent. © 2010 Elsevier Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
