White paper on best practices for translational research in neuroendocrine neoplasms

Basic and translational investigations play a crucial role in advancing our understanding of neuroendocrine neoplasms (NENs). In this white paper by the Basic and Translational Research Group of the European Neuroendocrine Tumor Society, we discuss the qualities and drawbacks of current disease models and propose good practices for integrating state-of-the-art technologies including bulk and single-cell genomics, transcriptomics, and proteomics in contemporary NEN research. We also provide insights on how to properly handle tissue samples (particularly when starting material is limited) and discuss technical hints of relevance when planning liquid biopsy or tumor immunology studies. Future translational studies of NENs will benefit from centralized biologic material biobanking, research design planning in the context of multi-expertise committees, as well as experimental protocol optimization and sharing across the NEN scientific community.