The physiological role of the inwardly rectifying potassium channel, Kir5.1, is poorly understood, as is the molecular identity of many renal potassium channels. In this study we have used Kir5.1-specific antibodies to reveal abundant expression of Kir5.1 in renal tubular epithelial cells, where Kir4.1 is also expressed. Moreover, we also show that Kir5.1/Kir4.1 heteromeric channel activity is extremely sensitive to inhibition by intracellular acidification and that this novel property is conferred predominantly by the Kir5.1 subunit. These findings suggest that Kir5.1/Kir4.1 heteromeric channels are likely to exist in vivo and implicate an important and novel functional role for the Kir5.1 subunit.
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|Titolo:||pH Dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia|
|Data di pubblicazione:||2000|
|Citazione:||pH Dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia / S.J. TUCKER; P. IMBRICI; L. SALVATORE; M.C. D'ADAMO; M. PESSIA. - In: THE JOURNAL OF BIOLOGICAL CHEMISTRY. - ISSN 0021-9258. - 275:22(2000), pp. 16404-16407.|
|Appare nelle tipologie:||1.1 Articolo in rivista|