Progressive renal regardless of the initiating insult, is characterized by glomerulosclerosis, tubulointerstitial fibrosis and vascular sclerosis. The severity of the tubulointerstitial fibrosis closely parallels the decline in renal function. Primary mechanisms of progressive scarring of the tubulointerstitium include up-regulated tubular expression of cytokines and extracellular matrix, adverse consequences of infiltrating macrophages, and possible epithelial-mesenchymal transdifferentiation, resulting in a profibrotic interstitial infiltrate. Better understanding of the mechanisms involved the potential to result in the recognition of new targets for pharmacologie interventions. © 2004 Elsevier Ltd. All rights reserved.
Mechanisms leading to progression of chronic renal injury: The interstitium
Rossini M.;
2004-01-01
Abstract
Progressive renal regardless of the initiating insult, is characterized by glomerulosclerosis, tubulointerstitial fibrosis and vascular sclerosis. The severity of the tubulointerstitial fibrosis closely parallels the decline in renal function. Primary mechanisms of progressive scarring of the tubulointerstitium include up-regulated tubular expression of cytokines and extracellular matrix, adverse consequences of infiltrating macrophages, and possible epithelial-mesenchymal transdifferentiation, resulting in a profibrotic interstitial infiltrate. Better understanding of the mechanisms involved the potential to result in the recognition of new targets for pharmacologie interventions. © 2004 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
