Elevation of tTG-IgA Antibodies in A Prospective Cohort of Children at Risk for Celiac Disease: Insights from the CDGEMM Cohort

Celiac Disease (CeD) is a common immune mediated condition that occurs in genetically predisposed individuals. Here we examined the trajectory of tissue transglutaminase IgA (tTG-IgA) antibodies in a prospective longitudinal cohort of over 500 children at-risk of developing CeD due to having a first-degree relative with CeD. We identified 34 subjects from our cohort and examined tTG-IgA titers at seroconversion and 6 months before tTG-IgA seroconversion. We found that all subjects had normal tTG-IgA 6 months prior to seroconversion. Thus, we conclude that tTG-IgA elevation in subjects with CeD is a sudden event and its trajectory cannot be used as a marker to predict seroconversion in this population.