: We carried out the first systematic review assessing if assessment of blinding was conducted in randomized controlled trials (RCTs) investigating medications for ADHD. We analyzed 161 double-blind RCTs of ADHD medications. We found only 1 RCT in which participants' awareness of study arm allocation was assessed and reported. Our findings are not meant to invalidate the evidence on the benefits of ADHD medications, which is supported by a large body of evidence. However, our findings suggest an opportunity to improve reporting of clinical trials in ADHD.
Systematic Review: Assessment of Blinding Integrity in 161 Randomized Controlled Trials of Medications for Attention-Deficit/Hyperactivity Disorder
Cortese, Samuele
2024-01-01
Abstract
: We carried out the first systematic review assessing if assessment of blinding was conducted in randomized controlled trials (RCTs) investigating medications for ADHD. We analyzed 161 double-blind RCTs of ADHD medications. We found only 1 RCT in which participants' awareness of study arm allocation was assessed and reported. Our findings are not meant to invalidate the evidence on the benefits of ADHD medications, which is supported by a large body of evidence. However, our findings suggest an opportunity to improve reporting of clinical trials in ADHD.File in questo prodotto:
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