In this work we report a waste-minimized continuous flow process for the synthesis of β-aminocarbonyls through hydration of N-Boc-2-azetines promoted under acid-catalysed conditions. The greenness of the process is harnessed by the use of flow technology for handling a biphasic segmented flow and the use of an inline liquid-liquid separator allowing the recovery of both the eco-friendly organic solvent (CPME) and the reusable acidic aqueous phase.
Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines
Andresini M.;Colella M.;Dibenedetto R. S.;Degennaro L.;Luisi R.
2023-01-01
Abstract
In this work we report a waste-minimized continuous flow process for the synthesis of β-aminocarbonyls through hydration of N-Boc-2-azetines promoted under acid-catalysed conditions. The greenness of the process is harnessed by the use of flow technology for handling a biphasic segmented flow and the use of an inline liquid-liquid separator allowing the recovery of both the eco-friendly organic solvent (CPME) and the reusable acidic aqueous phase.File in questo prodotto:
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