Schizophrenia pathogenesis involves synaptic function and neurotransmitter systems critical for brain circuit functionality. Diverse biological pathways with polygenic architecture are potentially affected. We aimed to identify a set of genes implicated both in genetic risk and in differential expression in a brain circuit of three brain regions. We studied how gene-set-specific schizophrenia risk translated into brain circuit function.
Tensor-Based Decomposition Associates Striatal Gene Co-Expression With Increased Dopamine Signaling in Individuals at Genetic Risk for Schizophrenia
Sportelli, Leonardo;D'Ambrosio, Enrico;Passiatore, Roberta;Bertolino, Alessandro;Pergola, Giulio
2022-01-01
Abstract
Schizophrenia pathogenesis involves synaptic function and neurotransmitter systems critical for brain circuit functionality. Diverse biological pathways with polygenic architecture are potentially affected. We aimed to identify a set of genes implicated both in genetic risk and in differential expression in a brain circuit of three brain regions. We studied how gene-set-specific schizophrenia risk translated into brain circuit function.File in questo prodotto:
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