Tensor-Based Decomposition Associates Striatal Gene Co-Expression With Increased Dopamine Signaling in Individuals at Genetic Risk for Schizophrenia

Schizophrenia pathogenesis involves synaptic function and neurotransmitter systems critical for brain circuit functionality. Diverse biological pathways with polygenic architecture are potentially affected. We aimed to identify a set of genes implicated both in genetic risk and in differential expression in a brain circuit of three brain regions. We studied how gene-set-specific schizophrenia risk translated into brain circuit function.