RuvBL1 is an AAA+ ATPase involved in multiple cellular activities including proliferation, chromatin remodeling, gene expression and translation. High RuvBL1 expression correlates with a worse prognosis in HCC and other human tumors. Emerging data suggests that RuvBL1 might exert co-chaperone functions. Aim of this study is to investigate the relations between RuvBL1 and molecular chaperones in HCC.
RUVBL1 correlates with chaperones expression in HCC and its activity is required for HSF1-mediated stress response
Defazio, G.;
2024-01-01
Abstract
RuvBL1 is an AAA+ ATPase involved in multiple cellular activities including proliferation, chromatin remodeling, gene expression and translation. High RuvBL1 expression correlates with a worse prognosis in HCC and other human tumors. Emerging data suggests that RuvBL1 might exert co-chaperone functions. Aim of this study is to investigate the relations between RuvBL1 and molecular chaperones in HCC.File in questo prodotto:
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