Melanocortin-1 receptor (MC1R) and its variants have a pivotal role in melanin synthesis. However, MC1R has been associated to non-pigmen- tary pathways related to DNA-repair activities and inflammation. The aim of this review is to provide an up-to-date overview about the role of MC1R in the skin. Specifically, after summarizing the current knowledge about MC1R structure and polymorphisms, we report data concerning the correlation between MC1R, phenotypic traits, skin aging, other diseases and skin cancers and their risk assessment through genetic testing. (Cite this article as: Guida S, Puig S, Di Resta C, Sallustio F, Mangano E, Stabile G, et al. Melanocortin-1 receptor (MC1R): a review for dermatologists.
Melanocortin-1 receptor (MC1R): a review for dermatologists
Stefania GUIDA;Fabio SALLUSTIO;Gabriella GUIDASupervision
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2024-01-01
Abstract
Melanocortin-1 receptor (MC1R) and its variants have a pivotal role in melanin synthesis. However, MC1R has been associated to non-pigmen- tary pathways related to DNA-repair activities and inflammation. The aim of this review is to provide an up-to-date overview about the role of MC1R in the skin. Specifically, after summarizing the current knowledge about MC1R structure and polymorphisms, we report data concerning the correlation between MC1R, phenotypic traits, skin aging, other diseases and skin cancers and their risk assessment through genetic testing. (Cite this article as: Guida S, Puig S, Di Resta C, Sallustio F, Mangano E, Stabile G, et al. Melanocortin-1 receptor (MC1R): a review for dermatologists.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
