Oral-Gut Microbiome and Bone Health: Exploring Interplay

This review provides a comprehensive analysis of the intricate interplay among the gut microbiome (GM), bone health, interleukins, chronic periodontitis, and COVID-19 within a concise 300-word limit. It begins by exploring the symbiotic relationship between the GM and bone health, delineating their composition, functions, and influencing factors. The discussion seamlessly transitions to the interaction between the GM and bone metabolism, emphasizing nutrient absorption, microbial metabolites, specific bacteria, and immune modulation. Experimental evidence highlights the significant impact of the GM on bone health, elucidating the roles of microbial metabolites and bacterial strains. The analysis further investigates the complex nexus between interleukins, chronic periodontitis, and COVID-19, underscoring genetic variations and immune responses shaping susceptibility and severity in viral infections. Chronic periodontitis emerges as a crucial focal point for understanding systemic dysbiosis, with genetic factors, dysbiosis, and therapeutic approaches offering insights into risk assessment and potential interventions. The proposed shift in therapeutic strategies centers on addressing dysbiosis, immune dynamics, and endocrine balance to manage degenerative and infectious diseases effectively. In conclusion, this review navigates the intricate landscape of human physiology, weaving together diverse elements to provide a holistic understanding. It underscores the importance of ongoing research to unravel the complex interplay of genetics, immune responses, and systemic health, emphasizing the need for continued exploration in this field.