beta-Enamino esters or amides can be synthesized in a single step by a carbonylative coupling of alpha-chloroimines with alcohols or amines under Pd-catalysis. The methodology has been also applied to the preparation of heteroaryl acetic acid derivatives starting from chloromethyl heteroaromatic rings containing a C-N double bond. The in situ generation of a beta-imino acylpalladium species has been proposed as a key step for the process. (C) 2016 Published by Elsevier Ltd.
Synthesis of beta-enamino acid and heteroaryl acetic acid derivatives by Pd-catalyzed carbonylation of alpha-chloroimines and 2-chloromethyl aza-heterocycles
Perrone, S;Cannazza, G;Salomone, A
;Troisi, L
2016-01-01
Abstract
beta-Enamino esters or amides can be synthesized in a single step by a carbonylative coupling of alpha-chloroimines with alcohols or amines under Pd-catalysis. The methodology has been also applied to the preparation of heteroaryl acetic acid derivatives starting from chloromethyl heteroaromatic rings containing a C-N double bond. The in situ generation of a beta-imino acylpalladium species has been proposed as a key step for the process. (C) 2016 Published by Elsevier Ltd.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
