The Pd-catalyzed amino- and alkoxycarbonylation of aryl iodides has been exploited, for the first time, in a bioinspired Deep Eutectic Solvent and in gas-free conditions, by using Mo(CO)6 as the CO source. The method allows the preparation of carboxylic amides and esters in high yields (up to 99%), short reaction time (2 h) and in mild reaction conditions (80 °C), with a low catalyst loading (2.5 mol%). Noteworthy, in the case of N-hexylbenzamide, it has been demonstrated that both the catalyst and DES can be used for four consecutive runs, with a moderate decrease of catalytic efficiency. The methodology has been also applied to the preparation of an Active Pharmaceutical Ingredient used for the treatment of human scabies and lice
Gas‐Free Amino‐ and Alkoxycarbonylation of Aryl Iodides in a Bioinspired Deep Eutectic Solvent with Mo(CO)6 as a Safe CO Source
Paparella, Andrea Nicola;Papadia, Paride;Perrone, Serena
;Salomone, Antonio
2023-01-01
Abstract
The Pd-catalyzed amino- and alkoxycarbonylation of aryl iodides has been exploited, for the first time, in a bioinspired Deep Eutectic Solvent and in gas-free conditions, by using Mo(CO)6 as the CO source. The method allows the preparation of carboxylic amides and esters in high yields (up to 99%), short reaction time (2 h) and in mild reaction conditions (80 °C), with a low catalyst loading (2.5 mol%). Noteworthy, in the case of N-hexylbenzamide, it has been demonstrated that both the catalyst and DES can be used for four consecutive runs, with a moderate decrease of catalytic efficiency. The methodology has been also applied to the preparation of an Active Pharmaceutical Ingredient used for the treatment of human scabies and liceI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.