A general, safe and scalable reductive protocol, based on the in situ generation of H-2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.
Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C
Paparella, AN;Salomone, A
2022-01-01
Abstract
A general, safe and scalable reductive protocol, based on the in situ generation of H-2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.File in questo prodotto:
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Hydrogenations in DES Green Chem 2022.pdf
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Deep Eutectic Solvents meet safe hydrogenation_GC_2022_postprint.pdf
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