A general, safe and scalable reductive protocol, based on the in situ generation of H-2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.

Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C

Paparella, AN;Salomone, A
2022-01-01

Abstract

A general, safe and scalable reductive protocol, based on the in situ generation of H-2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/430304
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