T. evansi can affect all mammals and has a wide range of domestic and wild reservoirs. Diagnosis is made by detection of parasites in blood. This method has low sensitivity when the parasites are few in number (e.g., in reservoirs and wild mammals) or absent in blood while present in the nervous system; surveillance is consequently challenging. No vaccine is available because of the rapid changes in trypanosomal surface glycoproteins, supporting avoidance of immune responses. Very rare human cases have been described from India, Vietnam, Sri Lanka, and Egypt. Clinical presentation among humans is quite similar to the firs stage of the chronic form of human sleeping sickness caused by T. brucei.
Trypanosoma evansi
Otranto, Domenico
2022-01-01
Abstract
T. evansi can affect all mammals and has a wide range of domestic and wild reservoirs. Diagnosis is made by detection of parasites in blood. This method has low sensitivity when the parasites are few in number (e.g., in reservoirs and wild mammals) or absent in blood while present in the nervous system; surveillance is consequently challenging. No vaccine is available because of the rapid changes in trypanosomal surface glycoproteins, supporting avoidance of immune responses. Very rare human cases have been described from India, Vietnam, Sri Lanka, and Egypt. Clinical presentation among humans is quite similar to the firs stage of the chronic form of human sleeping sickness caused by T. brucei.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
