In recent years, fluoroiodomethane (CH2FI) has emerged as an easy-to-handle, non-ozone depleting agent and readily available platform for monofluoromethylation strategies. Recent applications in nucleophilic substitutions, lithiation reactions, transition-metal catalyzed transformations, radical processes, and 18F-radiolabelling chemistry showcase the potential of this reagent for the preparation of organofluorine compounds. In this minireview, we provide an update to the field covering the recent relevant literature on the use of CH2FI.

The synthetic versatility of fluoroiodomethane: recent applications as monofluoromethylation platform

Colella M.
Writing – Original Draft Preparation
;
Musci P.
Membro del Collaboration Group
;
Andresini M.
Membro del Collaboration Group
;
Spennacchio M.
Membro del Collaboration Group
;
Degennaro L.
Supervision
;
Luisi R.
Writing – Review & Editing
2022-01-01

Abstract

In recent years, fluoroiodomethane (CH2FI) has emerged as an easy-to-handle, non-ozone depleting agent and readily available platform for monofluoromethylation strategies. Recent applications in nucleophilic substitutions, lithiation reactions, transition-metal catalyzed transformations, radical processes, and 18F-radiolabelling chemistry showcase the potential of this reagent for the preparation of organofluorine compounds. In this minireview, we provide an update to the field covering the recent relevant literature on the use of CH2FI.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/428502
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