Effects of a combination of resveratrol and alpha-lipoic acid on body weight and adipose composition in women with PCOS: a preliminary pilot study

OBJECTIVE: Polycystic ovary syndrome is associated with reproductive and metabolic dysfunction; in fact, treatment aims in PCOS focus on optimizing healthy weight, im- proving underlying hormonal disturbances, pre- venting future reproductive and metabolic com- plications, and improving quality of life. PATIENTS AND METHODS: This pilot study con- sidered 8 overweight females (BMI > 30) in repro- ductive age with PCOS. Patients were treated with a galenical preparation mixture containing resver- atrol and alpha-lipoic acid in association with vita- min D, B and folic acid for 12 weeks, after which an- thropometric assessment was conducted. RESULTS: After 12 weeks of treatment, BMI, anthropometry and bioimpedance parameters were all reduced in the treated patients com- pared to baseline. CONCLUSIONS: The present nutraceutical combination resulted beneficial for improving the metabolic profile of women with PCOS, paving the way for new nutraceutical strategies for the management of metabolic disturbances in PC