Autoimmune blistering diseases have been associated with exposure to the severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2). In addition, oropharyngeal Pemphigus vulgaris appears to beassociated with the coronavirus. In order to understand the molecular basis linking SARS-CoV-2 andPemphigus vulgaris, this study explores the molecular mimicry hypothesis and analyzes the peptidesharing between the Pemphigus vulgaris autoantigen, i.e., Desmoglein 3 (Dsg-3), and the SARS-CoV-2proteome. Results indicate a low molecular mimicry level, still immunologically significant, betweenSARS-CoV-2 and Dsg-3.
COVID 19 and Pemphigus vulgaris: a potential correlation
Petruzzi M.
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2022-01-01
Abstract
Autoimmune blistering diseases have been associated with exposure to the severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2). In addition, oropharyngeal Pemphigus vulgaris appears to beassociated with the coronavirus. In order to understand the molecular basis linking SARS-CoV-2 andPemphigus vulgaris, this study explores the molecular mimicry hypothesis and analyzes the peptidesharing between the Pemphigus vulgaris autoantigen, i.e., Desmoglein 3 (Dsg-3), and the SARS-CoV-2proteome. Results indicate a low molecular mimicry level, still immunologically significant, betweenSARS-CoV-2 and Dsg-3.File in questo prodotto:
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