The efficacy of Botulinum toxin A in reducing muscle spasticity by different volumes of dilution

Objective: Spasticity is a speed-dependent increase in muscle tone associated with stiffness, enhanced osteotendinous reflexes, paresis, loss of fine motor control, and increased fatigue. The neural insult it self causes paresis, and the consequent immobilization of the paretic part of the body can cause adaptive shortening ofthe muscles and joint contractures. Infiltrative treatment with botulinum toxin typeA (BTX-A ) is effective, safe and with few side effects. Methods: 10 patients after different years of treatment with BTX-A of the brachial biceps (BB100U) and superficial flexor ofthe fingers (FSD 100U), show ed no clinical and instrumental efficacy; The functional benefit obtained in patients. is related to the evaluation of muscle changes evolved in spasticity and to the study of a treatment to prevent these changes.