Propargylic oxiranes 4a-e and aziridines 8a-c have been prepared from cinnamyl chloride through lithiation-alkylation with α-halo carbonyl compounds and α-chloro imines, respectively. The reaction with substituted α-halo carbonyl compounds and α-chloro imines proved to be highly E diastereoselective.
Lithiation of Cinnamyl Chloride: Stereoselective Synthesis of Propargylic Oxiranes and Aziridines
CAPRIATI, Vito;
2000-01-01
Abstract
Propargylic oxiranes 4a-e and aziridines 8a-c have been prepared from cinnamyl chloride through lithiation-alkylation with α-halo carbonyl compounds and α-chloro imines, respectively. The reaction with substituted α-halo carbonyl compounds and α-chloro imines proved to be highly E diastereoselective.File in questo prodotto:
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