Toothache and brain: Any connections?

Orofacial pain is a universal predicament, afflicting millions of individuals worldwide. Research on the molecular mechanisms of orofacial pain has predominately focused on the role of neurons underlying nociception. Orofacial pain can arise from different regions and etiologies. Temporomandibular disorders are the most prevalent orofacial pain conditions for which patients seek treatment. Pain on weak tactile stimulation is expected if dentinal terminate synaptically on trigeminal brainstem neurons that deliver a pain message to higher brain centers. Further studies are needed.