NeuroCOVID is a neuropsychiatric syndrome that overall occurs in 36%-84% of patients suffering from COVID-19 (corona virus disease-2019). The neuroCOVID symptoms are manifold and heterogeneous, show different levels of severity, and occur both in acute and subacute/chronic phase of the disease. Two types of neuropsychiatric symptoms can be distinguished on the basis of their pathogenesis: (i) symptoms due to the direct neuropathogenic effect of SARS CoV-2 (direct symptoms); (ii) symptoms related with indirect neuropathogenic effect of the virus, mediated by hypoxic/ischemic or by immunopathological mechanisms activated during SARS CoV-2 infection (indirect symptoms). Aim of this review was to analyze the main neuropsychiatric symptoms of the neuroCOVID and accurately examine, for each of them, facts and advanced hypotheses to explain their pathogenesis.
Pathogenesis of NeuroCOVID: Views after Two Years of Pandemic
Anna Rizzi;Matteo Saccia;Vincenzo Benagiano
2022-01-01
Abstract
NeuroCOVID is a neuropsychiatric syndrome that overall occurs in 36%-84% of patients suffering from COVID-19 (corona virus disease-2019). The neuroCOVID symptoms are manifold and heterogeneous, show different levels of severity, and occur both in acute and subacute/chronic phase of the disease. Two types of neuropsychiatric symptoms can be distinguished on the basis of their pathogenesis: (i) symptoms due to the direct neuropathogenic effect of SARS CoV-2 (direct symptoms); (ii) symptoms related with indirect neuropathogenic effect of the virus, mediated by hypoxic/ischemic or by immunopathological mechanisms activated during SARS CoV-2 infection (indirect symptoms). Aim of this review was to analyze the main neuropsychiatric symptoms of the neuroCOVID and accurately examine, for each of them, facts and advanced hypotheses to explain their pathogenesis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
