The effects of dantrolene sodium on the spontaneous and oxytocin-induced contractions of guinea-pig uterus were studied in vitro. Dantrolene reversibly increased the spontaneous contraction frequency of guinea-pig uterus. The effect was not dose-related and was not antagonized by atropine, methysergide or indomethacin. Dantrolene dose dependently and reversibly reduced the contractile responses of guinea-pig uterus to oxytocin. The varying effects of dantrolene on the uterus probably involve inhibition of calcium movement at more than one site of the muscle
DANTROLENE SODIUM: STIMULATORY AD DEPRESSANT EFFECTS ON THE CONTRACTILITY OF GUINEA-PIG UTERUS IN VITRO.
CONTE, Diana;
1983-01-01
Abstract
The effects of dantrolene sodium on the spontaneous and oxytocin-induced contractions of guinea-pig uterus were studied in vitro. Dantrolene reversibly increased the spontaneous contraction frequency of guinea-pig uterus. The effect was not dose-related and was not antagonized by atropine, methysergide or indomethacin. Dantrolene dose dependently and reversibly reduced the contractile responses of guinea-pig uterus to oxytocin. The varying effects of dantrolene on the uterus probably involve inhibition of calcium movement at more than one site of the muscleFile in questo prodotto:
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