The authors provide a report on the preparation of an extemporaneous liquid formulation of diazepam enema using an alcohol-free base solution for use by both pediatric and adult patients. A solubility study using this base and the chemical stability of the drug in this formulation was performed by using a high-pressure liquid chromatography analytical method. Results of this study showed that the intrinsic solubility of the drug in this liquid base was 6.03 mg/mL ± 0.06 mg/mL and that diazepam was chemically stable when the formulation was stored at 25°C over a period of 3 months.
Stability of Diazepam Enema Extemporaneous Formulation in Manzoni Base
Lopalco A.;Lopedota A.;Franco M.;Denora N.
2021-01-01
Abstract
The authors provide a report on the preparation of an extemporaneous liquid formulation of diazepam enema using an alcohol-free base solution for use by both pediatric and adult patients. A solubility study using this base and the chemical stability of the drug in this formulation was performed by using a high-pressure liquid chromatography analytical method. Results of this study showed that the intrinsic solubility of the drug in this liquid base was 6.03 mg/mL ± 0.06 mg/mL and that diazepam was chemically stable when the formulation was stored at 25°C over a period of 3 months.| File | Dimensione | Formato | |
|---|---|---|---|
|
Lopalco 27-9 -- IJPC 2021-427-DIAZEPAM IN MANZONI BASE.pdf
non disponibili
Tipologia:
Documento in Versione Editoriale
Licenza:
Copyright dell'editore
Dimensione
2.14 MB
Formato
Adobe PDF
|
2.14 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
|
DIazepam enema Manuscript IJPC_Pre-print.pdf
accesso aperto
Tipologia:
Documento in Pre-print
Licenza:
Non specificato
Dimensione
217.32 kB
Formato
Adobe PDF
|
217.32 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
