Post-surgical pre-implantar bone defects regeneration in pediatric patients with sodium hyaluronate and amino acids

This study was designed to evaluate whether a sterile gel formulation of sodium hyaluronate and amino acids Gly-Pro-Leu-Lys (AMINOGAM®) is effective in accelerating post-surgical and pre-implantar bone defects regeneration in pediatric patients. We evaluated different healing in 28 bone defects, divided in 2 groups: test group treated with intracavitary intraoperative filling of gel and control group without gel. Outcomes were evaluated by clinical and radiographic follow-up through grey scale densitometry. Defects treatment after bone healing in both groups was completed with histological pre-implantar examination through trephine drill and insertion of implants. Clinical and radiographic evaluations of the implants were performed at 12 months after functional loading. Soft tissues outcomes in test group show immediate haemostatic effect, pain and swelling decrease and infective complication dejection (0%) compared to control group (6%). Gel reduces removing stitches time at 6 days in test group compared to 14 days in control group. Hard tissues outcomes show faster healing time: 30% difference between ossification level in test and control group at 2 months. The difference decrease in following months until 3% at 12 months. Pre-implantar bone specimen get with 2,5mm trephine drill shows a more dense and mature lamellar bone with twisted fiber and different calcification level allowing early implant insertion at 30-45 days in test group compared to 60 days in control group.