Deletionsadjacenttothe9/22translocationbreakpointonthederivativechromosome9haverecentlybeendescribedina substantialnumberofchronicmyeloidleukemia(CML)cases,buttheirextensionhasnotbeencharacterizedindetail.Using FISHwithanappropriatesetofBAC/PACprobes,wehavecharacterizedthedeletionin10CMLcases, identifiedbyscreening 71patientsatdiagnosis.Fivepatientsshowedacomplexchromosomerearrangementand3ofthemweredeleted.Thesizeofthe deletionwasvariable, rangingfromfewhundredskbto8Mb.Aminimallydeletedregiononbothchromosomes9and22was identifiedandwasfoundtocontaintheASSgeneonchromosome9andIGLL1onchromosome22
Characterization of der(9) deletions in CML patients
STORLAZZI, CLELIA TIZIANA;ANELLI, LUISA;ALBANO, FRANCESCO;ROCCHI, Mariano;
2002-01-01
Abstract
Deletionsadjacenttothe9/22translocationbreakpointonthederivativechromosome9haverecentlybeendescribedina substantialnumberofchronicmyeloidleukemia(CML)cases,buttheirextensionhasnotbeencharacterizedindetail.Using FISHwithanappropriatesetofBAC/PACprobes,wehavecharacterizedthedeletionin10CMLcases, identifiedbyscreening 71patientsatdiagnosis.Fivepatientsshowedacomplexchromosomerearrangementand3ofthemweredeleted.Thesizeofthe deletionwasvariable, rangingfromfewhundredskbto8Mb.Aminimallydeletedregiononbothchromosomes9and22was identifiedandwasfoundtocontaintheASSgeneonchromosome9andIGLL1onchromosome22File in questo prodotto:
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