Immunotherapy is a promising therapeutic strategy both for solid and hematologic tumors, such as in Hodgkin (HL) and non-Hodgkin lymphoma (NHL). In particular, immune-checkpoint inhibitors, such as nivolumab and pembrolizumab, are increasingly used for the treatment of re-fractory/relapsed HL. At the same time, evidence of chimeric antigen receptor (CAR)-T-cell im-munotherapy efficacy mostly in NHL is growing. In this setting, the challenge is to identify an appro-priate imaging method to evaluate immunotherapy response. The role of 18F-Fluorodeoxyglucose (18F-FDG) positron-emission tomography/computed tomography (PET/CT), especially in early evaluation, is under investigation in order to guide therapeutic strategies, taking into account the possible atypical responses (hyperprogression and pseudoprogression) and immune-related adverse events that could appear on PET images. Herein, we aimed to present a critical overview about the role of 18F-FDG PET/CT in evaluating treatment response to immunotherapy in lymphoma patients.
Early evaluation of immunotherapy response in lymphoma patients by 18f-fdg pet/ct: A literature overview
Ferrari C.
;Maggialetti N.;Masi T.;Nappi A.;Santo G.;Asabella A. N.;Rubini G.
2021-01-01
Abstract
Immunotherapy is a promising therapeutic strategy both for solid and hematologic tumors, such as in Hodgkin (HL) and non-Hodgkin lymphoma (NHL). In particular, immune-checkpoint inhibitors, such as nivolumab and pembrolizumab, are increasingly used for the treatment of re-fractory/relapsed HL. At the same time, evidence of chimeric antigen receptor (CAR)-T-cell im-munotherapy efficacy mostly in NHL is growing. In this setting, the challenge is to identify an appro-priate imaging method to evaluate immunotherapy response. The role of 18F-Fluorodeoxyglucose (18F-FDG) positron-emission tomography/computed tomography (PET/CT), especially in early evaluation, is under investigation in order to guide therapeutic strategies, taking into account the possible atypical responses (hyperprogression and pseudoprogression) and immune-related adverse events that could appear on PET images. Herein, we aimed to present a critical overview about the role of 18F-FDG PET/CT in evaluating treatment response to immunotherapy in lymphoma patients.File | Dimensione | Formato | |
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jpm-11-00217-v2.pdf
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