On the basis of studies conducted on an acetaminophen-induced model of hepatotoxicity in large animals that we previously described, we have defined a new model for acute hepatic failure that lends itself to this type of study. Our results report for the first time a model of acute hepatic failure in a large animal that can be easily reproduced in any laboratory. This model satisfies all of the criteria for a suitable animal model of acute hepatic failure. The use of this model in liver transplantation will be useful to better define the clinical indications for orthotopic liver transplantation, and to gain further insight into the pathophysiology of this acute and deadly process.
A novel model of acute hepatic failure in dogs with implications for transplantation research
Francavilla A.;Barone M.;Ambrosino G.;
1988-01-01
Abstract
On the basis of studies conducted on an acetaminophen-induced model of hepatotoxicity in large animals that we previously described, we have defined a new model for acute hepatic failure that lends itself to this type of study. Our results report for the first time a model of acute hepatic failure in a large animal that can be easily reproduced in any laboratory. This model satisfies all of the criteria for a suitable animal model of acute hepatic failure. The use of this model in liver transplantation will be useful to better define the clinical indications for orthotopic liver transplantation, and to gain further insight into the pathophysiology of this acute and deadly process.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
