Alkoxide-mediated enolization of 1-arylpropan-2-ones and their fluorinated derivatives, followed by α-functionalization with nucleophilic addition and substitution reactions, has been accomplished in the enviromentally friendly eutectic mixture choline chloride/urea, under aerobic conditions. The usefulness of this new protocol has also been exemplified through the synthesis of a small selection of building-block like molecules through Pd-catalyzed α-arylation reactions
Introducing Deep Eutectic Solvents in Enolate Chemistry: Synthesis of 1-Arylpropan-2-ones under Aerobic Conditions
Vitale, Paola
;Cicco, Luciana;Perna, Filippo M.;Capriati, Vito
2021-01-01
Abstract
Alkoxide-mediated enolization of 1-arylpropan-2-ones and their fluorinated derivatives, followed by α-functionalization with nucleophilic addition and substitution reactions, has been accomplished in the enviromentally friendly eutectic mixture choline chloride/urea, under aerobic conditions. The usefulness of this new protocol has also been exemplified through the synthesis of a small selection of building-block like molecules through Pd-catalyzed α-arylation reactionsFile in questo prodotto:
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