Minimally Invasive “IPG-Det Technique” with Autologous CGF and Human Umbilical Cord Blood Derived Mesenchymal Stem Cells towards Posterior Atrophic Maxilla Reconstruction - Case Report

Rehabilitation of maxilla in Implant Dentistry, especially in posterior edentulism is primarily treated with large and painful surgical approaches due to residual ridge atrophy and maxillary sinus pneumatization. Sinus Floor Elevation (SFE), especially in its “lateral version” is considered as the “gold-standard” for over four decades, despite the well documented post-operative morbidity and complications. As an alternative, the novel protocol named “IPG-DET Technique” minimally invasive and equally safe-efficient, promotes sinus membrane intentional perforation secured by healing and augmentative potential of autologous concentrated growth factors and CD34-Stem Cells Matrix. This study further investigates the efficiency and healing process of “IPG-DET Technique” amplified by Mesenchymal Stem Cells clinical use, derived from human Umbilical Cord Blood for posterior atrophic maxilla reconstruction. Preliminary results have shown safe and inductive bone regeneration within sinus cavity. All implants loaded, 4 months after implant placement, showed high primary stability until final fixed prosthetic rehabilitation.