Non-Alcoholic Fatty Liver Disease (NAFLD) comprises a wide spectrum of liver injuries from simple steatosis to steatohepatitis and cirrhosis. Non-Alcoholic Steatohepatitis (NASH) is defined when liver steatosis is associated with inflammation, hepatocyte damage and fibrosis. Genetic predisposition and environmental insults (i.e. dietary habits, obesity) are putative responsible for NASH progression. Here, we present the impact of the lipid-sensing nuclear receptors in the pathogenesis and treatment of NASH. In details, we discuss pros and cons of the putative transcriptional action of the fatty acid sensors (peroxisome proliferator activated receptors PPARs) of the bile acid sensor (farnesoid X receptor FXR) and of the oxysterol sensor (liver X receptors LXR) in the pathogenesis and bona fide treatment of NASH.

Transcriptional regulation of metabolic pathways via lipid-sensing nuclear receptors PPARs, FXR and LXR in NASH

Cariello, Marica;Piccinin, Elena;Moschetta, Antonio
2021-01-01

Abstract

Non-Alcoholic Fatty Liver Disease (NAFLD) comprises a wide spectrum of liver injuries from simple steatosis to steatohepatitis and cirrhosis. Non-Alcoholic Steatohepatitis (NASH) is defined when liver steatosis is associated with inflammation, hepatocyte damage and fibrosis. Genetic predisposition and environmental insults (i.e. dietary habits, obesity) are putative responsible for NASH progression. Here, we present the impact of the lipid-sensing nuclear receptors in the pathogenesis and treatment of NASH. In details, we discuss pros and cons of the putative transcriptional action of the fatty acid sensors (peroxisome proliferator activated receptors PPARs) of the bile acid sensor (farnesoid X receptor FXR) and of the oxysterol sensor (liver X receptors LXR) in the pathogenesis and bona fide treatment of NASH.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/359497
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 30
  • Scopus 58
  • ???jsp.display-item.citation.isi??? 50
social impact