Aim: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions. Methods: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/metastatic RCC. Results: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61-2.00; I 2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.42-2.01; I 2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients. Conclusion: The NLR ratio is a variable correlated to prognosis in RCC patients.
Prognostic impact of neutrophil-to-lymphocyte ratio in renal cell carcinoma: A systematic review and meta-analysis
Porta C.;
2019-01-01
Abstract
Aim: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions. Methods: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/metastatic RCC. Results: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61-2.00; I 2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.42-2.01; I 2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients. Conclusion: The NLR ratio is a variable correlated to prognosis in RCC patients.| File | Dimensione | Formato | |
|---|---|---|---|
|
Immunotherapy 2019 [N-L ratio in RCC].pdf
non disponibili
Descrizione: Article
Tipologia:
Documento in Versione Editoriale
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
1.32 MB
Formato
Adobe PDF
|
1.32 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
