Spectral-domain optical coherence tomography and fluorescein angiography features of cystoid macular edema with serous retinal detachment secondary to intracameral cefuroxime administration

We present 3 cases of acute-onset cystoid macular edema (CME) with serous retinal detachment (RD) attributable to intracameral injection of a standard dose of cefuroxime at the end of uneventful cataract surgery. Other possible causes of CME, such as diabetic retinopathy, retinal vascular occlusion, uveitis, choroidal neovascularization, vitreomacular traction, and concomitant medications, were excluded. The clinical features seen in the spectral-domain optical coherence tomographic and angiographic patterns of this particular retinal disorder are compared with those reported in the literature. To our knowledge, this is the first reported spectral-domain optical coherence tomographic–documentation of a serous RD that extends beyond the vascular arcades secondary to intracameral cefuroxime administration. The pathogenetic mechanism that leads to this particular retinal abnormality is discussed. Financial Disclosure None of the authors has a financial or proprietary interest in any material or method mentioned.