The synthesis of SM-9064, a potential LTB4 antagonist, which is effective in some types of inflammation, has been easily achieved in a few steps by electrophilic substitution reactions between (1E,3E,5E)-1,6-bis(trimethylsilyl)-1,3,5-hexatriene and acyl chlorides in the presence of aluminum trichloride, followed by reduction reaction and formation of pyrrolidine derivative.
A direct access to a potential LTB4-antagonist, SM-9064, via disilyl derivatives
PUNZI, Angela
1993-01-01
Abstract
The synthesis of SM-9064, a potential LTB4 antagonist, which is effective in some types of inflammation, has been easily achieved in a few steps by electrophilic substitution reactions between (1E,3E,5E)-1,6-bis(trimethylsilyl)-1,3,5-hexatriene and acyl chlorides in the presence of aluminum trichloride, followed by reduction reaction and formation of pyrrolidine derivative.File in questo prodotto:
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