Carcinogens in cigarette smoke may leave fingerprints in the bronchial tissue in the form of specific mutations that initiate cancer development [1]. Numerous genetic alterations have been recognised as critical effects of cigarette smoke and studied in the airways of current and former smokers. Microsatellite alterations (MAs) at 3p and 19q are among the most studied, being considered useful markers of genetic susceptibility and genome destabilisation in susceptible smokers [2, 3]. Instability and/or loss of heterozygosity at 3p and 19q have largely been reported in the lung tissue, sputum and blood of smokers and lung tumour patients [2, 4]. These mutations, which are considered an early effect of cigarette smoke, are dose-dependent and related to the number of cigarettes smoked in a lifetime [3]. In addition, short-term exposure to cigarette smoke seems to cause MAs at 3p that are not necessarily a consequence of the development of a neoplastic mass [5].
Microsatellite alterations at 3p and 19q in EBC DNA of smokers: Are they reversible after smoking cessation?
Carpagnano G. E.;
2011-01-01
Abstract
Carcinogens in cigarette smoke may leave fingerprints in the bronchial tissue in the form of specific mutations that initiate cancer development [1]. Numerous genetic alterations have been recognised as critical effects of cigarette smoke and studied in the airways of current and former smokers. Microsatellite alterations (MAs) at 3p and 19q are among the most studied, being considered useful markers of genetic susceptibility and genome destabilisation in susceptible smokers [2, 3]. Instability and/or loss of heterozygosity at 3p and 19q have largely been reported in the lung tissue, sputum and blood of smokers and lung tumour patients [2, 4]. These mutations, which are considered an early effect of cigarette smoke, are dose-dependent and related to the number of cigarettes smoked in a lifetime [3]. In addition, short-term exposure to cigarette smoke seems to cause MAs at 3p that are not necessarily a consequence of the development of a neoplastic mass [5].I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
