The cobalt(II)acetylacetonate/aldehyde-promoted aerobic oxidation of three bis-sulfides of general formula R1- SCH2CH2S-R2, where R1 is a heterocycle and R2 is p-tolyl, provides a method to functionalise selectively the sulfur atom bonded to the p-tolyl moiety leading to the corresponding monosulfoxides. The same chemoselectivity and little diastereoisomeric excess (10%). was achieved by submitting to oxidative conditions the chiral bis-sulfide (5)-R3- SCH2CHCH3.CH2-SR4 (R3sbenzothiazolyl, R4sp-tolyl).
Regioselective aerobic oxidation of bis-sulfides into monosulfoxides
NACCI, Angelo
2000-01-01
Abstract
The cobalt(II)acetylacetonate/aldehyde-promoted aerobic oxidation of three bis-sulfides of general formula R1- SCH2CH2S-R2, where R1 is a heterocycle and R2 is p-tolyl, provides a method to functionalise selectively the sulfur atom bonded to the p-tolyl moiety leading to the corresponding monosulfoxides. The same chemoselectivity and little diastereoisomeric excess (10%). was achieved by submitting to oxidative conditions the chiral bis-sulfide (5)-R3- SCH2CHCH3.CH2-SR4 (R3sbenzothiazolyl, R4sp-tolyl).File in questo prodotto:
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