Fostemsavir, a novel attachment inhibitor targeting the HIV-1 gp120, has demonstrated wide in vitro activity. However, the high rate of HIV gp120 substitutions could jeopardize its efficacy. We investigated envelope (env) substitutions at positions associated with resistance to fostemsavir in patients with a new HIV-1 diagnosis according to HIV subtype and tropism.
Gp120 substitutions at positions associated with resistance to fostemsavir in treatment-naive HIV-1-positive individuals
Lepore, Luciana;Fabrizio, Claudia;Bavaro, Davide Fiore;Milano, Eugenio;Volpe, Anna;Lagioia, Antonella;Angarano, Gioacchino;Saracino, Annalisa;Monno, Laura
2020-01-01
Abstract
Fostemsavir, a novel attachment inhibitor targeting the HIV-1 gp120, has demonstrated wide in vitro activity. However, the high rate of HIV gp120 substitutions could jeopardize its efficacy. We investigated envelope (env) substitutions at positions associated with resistance to fostemsavir in patients with a new HIV-1 diagnosis according to HIV subtype and tropism.File in questo prodotto:
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