The effects of thymoxamine on the contractions induced in guinea pig isolated ileum were examined. The drug was tested in a large range of concentrations (10-8-10-4 M). The twitch response induced by acetylcholine was potentiated by low concentrations and inhibited by high concentrations of the α-blocking drug thymoxamine. The contractions in response to carbachol were always inhibited. Thymoxamine also affected the responses of the ileum to other stimulants: angiotensin, pentagastrin, cholecystokinin. The drug (8 x 10-5, 5 x 10-4 M) inhibited the calcium contraction of high K+ depolarized preparations
The effects of thymoxamine on guinea pig ileum contractions
CONTE, Diana
1984-01-01
Abstract
The effects of thymoxamine on the contractions induced in guinea pig isolated ileum were examined. The drug was tested in a large range of concentrations (10-8-10-4 M). The twitch response induced by acetylcholine was potentiated by low concentrations and inhibited by high concentrations of the α-blocking drug thymoxamine. The contractions in response to carbachol were always inhibited. Thymoxamine also affected the responses of the ileum to other stimulants: angiotensin, pentagastrin, cholecystokinin. The drug (8 x 10-5, 5 x 10-4 M) inhibited the calcium contraction of high K+ depolarized preparationsFile in questo prodotto:
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