Cardiac hypertrophy/remodeling is a critical condition that if not efficiently contrasted may predispose to fatal heart failure and multiple organ dysfunction as a result of irreversible neuroendocrine, autonomic and immune system imbalances. Indeed, in chronic heart failure (CHF) the over-excitation of sympathetic and/or the breakdown of central parasympathetic tone are believed to be the basis of the persistent immune activation that in part is primed by inflammatory reactions in the Central Nervous System. Moreover, the clinical management of CHF still today requires the identification of molecularly targeted drugs alternative to those considered so far. In this review are focused the possible neuroimmune-mediated pathways involved in CHF and set out the current therapeutic strategies.
Neuroimmune activation in chronic heart failure
Fiore G.;Suppress P.;Triggiani V.;Resta F.;Sabba C.
2013
Abstract
Cardiac hypertrophy/remodeling is a critical condition that if not efficiently contrasted may predispose to fatal heart failure and multiple organ dysfunction as a result of irreversible neuroendocrine, autonomic and immune system imbalances. Indeed, in chronic heart failure (CHF) the over-excitation of sympathetic and/or the breakdown of central parasympathetic tone are believed to be the basis of the persistent immune activation that in part is primed by inflammatory reactions in the Central Nervous System. Moreover, the clinical management of CHF still today requires the identification of molecularly targeted drugs alternative to those considered so far. In this review are focused the possible neuroimmune-mediated pathways involved in CHF and set out the current therapeutic strategies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
