Influence of prebiotic administration on inflammatory and glycaemic markers in type-2 diabetes

Prebiotics are often administered with the daily diet: they have been widely investigated in recent years, and several researchers have assessed that pthey can favorably affect health and cell aging. Prebiotics seem to actively enhance several antioxidant pathways that overall improve the immune homeostasis, also increasing the suppression of chronic inflammation and the prevention of insulin resistance (1). Prebiotics may promote changes in the bacterial composition and/or in the main activities of the gastrointestinal tract; moreover, they have been shown to improve the gut environment and its microbiome, often closely associated with the onset and severity of type-2 diabetes mellitus (T2DM). Furthermore, prebiotics can modulate the production of haemoglobin- A1c (HbA1c), thus modulating the glycaemic values detected just after lunch. Finally, prebiotics have been associated with a slight reduction of the main inflammatory markers, in T2DM patients (1,2).