Adenomyoepithelioma

Adenomyoepithelioma (AME) is a benign tumor of the breast, composed by a biphasic proliferation of phenotypically distinct myoepithelial cells and luminal epithelial cells. Following the first description by Hamperl (1970), Tavassoli (1991) identified three histologic variants, in which myoepithelial and epithelial cells are present in variable percentages, namely, spindle, tubular, and lobulated AME (Tavassoli 1991). AME with malignant features ( Malignant Adenomyoepithelioma (M-AME)) have seldom been reported (Hayes 2011) and named AME with carcinoma, when epithelial cells or myoepithelial cells show malignant cytomorphological features and malignant AME when these are present in both components (Brogi 2014).