Background Intubator-Associated Pneumonia (IAP) is a common healthcare-associated infection with significant mortality, morbidity and healthcare costs, and rates have been proposed as a potential quality indicator. An increase in the IAP rates was shown by the ‘‘Italian Nosocomial Infections Surveillance in Intensive Care Units (ICUs) network’’ (SPIN-UTI). The aim of the present study was to estimate the preventable proportion (PP) of IAPs in ICUs participating in the fourth edition of the SPIN-UTI project. Methods From October 2012 to July 2013 patient-based surveillance data were collected according to the ECDC HAIICU protocol (vs. 1.2). Using the parametric G-formula for time-to-event data, we estimated the expected number of IAP and the IAP incidences that would be realized if ICUs with higher IAP incidence rates in the database had the same IAP incidence of reference ICUs (the top 10th percentile ranked ICU for the IAP incidence distribution), after adjustment (i.e. standardization) for patients and ICU characteristics. The PP of IAP was calculated as observed cases minus expected cases divided by observed cases. Results A total of 1840 intubated patients from 17 ICUs were enrolled. Overall, IAP incidence was 11.7 per 100 intubated patients and IAP rate was 11.8 per 1000 intubator-days. In the unadjusted model the PP of IAP was 0.82 (CI95%: 0.78-0.86); the PP was 0.47 (CI95%: 0.40-0.54) after standardization for case-mix. Conclusions Based on European surveillance data collected by the National ICU networks, more than 52% of ventilator-associated pneumonia could have been avoided (Lambert et al, 2014). Similarly, in the SPIN-UTI network, if IAP rates of ICUs with higher infection rates could have been reduced to that of the 10th percentile-ranked ICUs, then about 47% of IAPs could have been prevented by the implementation of preventive measures. Project realized with financial support by Ministry of Health –CCM.

Preventable proportion of Intubator-Associated Pneumonia in Italian ICUs: a G-computation analysis

MT Montagna;
2016

Abstract

Background Intubator-Associated Pneumonia (IAP) is a common healthcare-associated infection with significant mortality, morbidity and healthcare costs, and rates have been proposed as a potential quality indicator. An increase in the IAP rates was shown by the ‘‘Italian Nosocomial Infections Surveillance in Intensive Care Units (ICUs) network’’ (SPIN-UTI). The aim of the present study was to estimate the preventable proportion (PP) of IAPs in ICUs participating in the fourth edition of the SPIN-UTI project. Methods From October 2012 to July 2013 patient-based surveillance data were collected according to the ECDC HAIICU protocol (vs. 1.2). Using the parametric G-formula for time-to-event data, we estimated the expected number of IAP and the IAP incidences that would be realized if ICUs with higher IAP incidence rates in the database had the same IAP incidence of reference ICUs (the top 10th percentile ranked ICU for the IAP incidence distribution), after adjustment (i.e. standardization) for patients and ICU characteristics. The PP of IAP was calculated as observed cases minus expected cases divided by observed cases. Results A total of 1840 intubated patients from 17 ICUs were enrolled. Overall, IAP incidence was 11.7 per 100 intubated patients and IAP rate was 11.8 per 1000 intubator-days. In the unadjusted model the PP of IAP was 0.82 (CI95%: 0.78-0.86); the PP was 0.47 (CI95%: 0.40-0.54) after standardization for case-mix. Conclusions Based on European surveillance data collected by the National ICU networks, more than 52% of ventilator-associated pneumonia could have been avoided (Lambert et al, 2014). Similarly, in the SPIN-UTI network, if IAP rates of ICUs with higher infection rates could have been reduced to that of the 10th percentile-ranked ICUs, then about 47% of IAPs could have been prevented by the implementation of preventive measures. Project realized with financial support by Ministry of Health –CCM.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/279921
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