Adenocarcinomi del digiuno in maschi adulti con preesistenti malattie intestinali non neoplastiche

Small bowel carcinomas era extremely rare. They usually represent the 2% of the gastrointestinal tumors. Most of them are represented by duodenal adenocarcinomas. The most predominant localization is represented by the duodenum. Less frequent forms are represented by jejunal and ileal tumors. These neoplasm are often associated with non-neoplastic diseases such as celiac disease or inflammatory bowel disease. Here are described two cases of jejunal adenocarcinomas. These tumors occurred in two young male adults, presented to our observation with bowel obstruction symptoms the frst, with bleeding the second. One of the patients was affected by celiac disease, the other reported a previous diagnosis of ulcerative colitis for which he was already in therapy. Both patients underwent surgery and a laparoscopic jejunal resection was performed. although in celiac patients with cancer is not evident any pre-malignant or dysplastic lesion close to the tumor, the adenoma-carcinoma sequence is still accepted. indeed, considering its invasive component, adenocarcinoma is able to replace completely the adenoma. Moreover, patients affected by inflammatory bowel diseases have a higher risk to develop carcinomas. In order to guarantee an early diagnosis of the carcinomas, we tried to establish relationships between these tumors and autoimmune diseases already diagnosed in some patients.