Anaplastic large-cell periprosthetic lymphoma of the breast: could fibrin be an early radiological indicator of the presence of disease?

Purpose: The onset characteristics of the anaplastic large cell lymphoma (BI-ALCL) are non-specific and the diagnosis is often difficult and based on clinical suspicion and cytological sampling. The presence of non-pathognomonic radiological signs may delay the diagnosis of BI-ALCL, influencing patient prognosis. This could have an important social impact, considering that the incidence of BI-ALCL correlates with the number of prosthetic implants, which is in constant increase worldwide. The aim of this study was to verify if fibrin can represent a potentially early radiological sign of the disease.Methods: In this study, we present two cases of our series and review the previous studies already described in the literature, searching for any early radiological sign of the disease and reporting a diagnostic work-up process for an early diagnosis.Results: Signs clearly recognizable only of magnetic resonance imaging (MRI) were the following: thickening and hyperemia of the fibrous capsule with seroma and amorphous material (fibrin) present in 8 out of 10 cases (80%), detected on MRI (certain or doubtful).Conclusion: The presence of fibrin in the periprosthetic effusion, well detectable by MRI, could represent an early pathognomonic sign of the disease.