Introduction: This work is focused on the study of the inhibition activity exerted by some donepezil derivatives, on the acetlycholinesterase and b-secretase 1 (Bace-1) activities, potentially useful as dual inhibitors for the treatment of Alzheimer’s disease (AD). Results: The Authors report the effect produced by some donepezil derivatives on the enzymatic activity of acetlycholinesterase and Bace-1. Conclusion: In vitro AChE activity inhibition represent an useful approach to identity molecular candidates for a more appropriate AD therapy.
Titolo: | DONEPEZIL DERIVATIVES AS DUAL ACETYLCHOLINESTERASE AND b-SECRETASE 1 INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE |
Autori: | |
Data di pubblicazione: | 2020 |
Rivista: | |
Handle: | http://hdl.handle.net/11586/265126 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
ACTA 2-2020 - NASSO, ASCIONE.pdf | Documento in Post-print | NON PUBBLICO - Accesso privato/ristretto | Administrator Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.