Introduction: This work is focused on the study of the inhibition activity exerted by some donepezil derivatives, on the acetlycholinesterase and b-secretase 1 (Bace-1) activities, potentially useful as dual inhibitors for the treatment of Alzheimer’s disease (AD). Results: The Authors report the effect produced by some donepezil derivatives on the enzymatic activity of acetlycholinesterase and Bace-1. Conclusion: In vitro AChE activity inhibition represent an useful approach to identity molecular candidates for a more appropriate AD therapy.

DONEPEZIL DERIVATIVES AS DUAL ACETYLCHOLINESTERASE AND b-SECRETASE 1 INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE

Ascione Antonio
2020

Abstract

Introduction: This work is focused on the study of the inhibition activity exerted by some donepezil derivatives, on the acetlycholinesterase and b-secretase 1 (Bace-1) activities, potentially useful as dual inhibitors for the treatment of Alzheimer’s disease (AD). Results: The Authors report the effect produced by some donepezil derivatives on the enzymatic activity of acetlycholinesterase and Bace-1. Conclusion: In vitro AChE activity inhibition represent an useful approach to identity molecular candidates for a more appropriate AD therapy.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/265126
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