White sponge nevus (WSN) is a rare and autosomal dominant disorder characterized by benign, white and spongy plaques of the various mucosae, especially of the oral mucosa. The lesions of WSN are nonpainful and may undergo alternate periods of remission and exacerbation. We report a case of WSN in a 23year-old woman with lesions affecting oral, vulvar, vaginal and cervical mucosae. The treatment with penicillin proved to be unsuccessful.
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