Vimentin, a member of cytoskeleton intermediate filaments proteins, plays a critical role in cell structure and dynamics. The present proteomic study reveals reduced amount of six different lengths, N-terminal truncated proteolytic products of vimentin, in the primary skin fibroblasts from two unrelated PD patients, as compared to control fibroblasts. The decreased amount of N-terminal truncated forms of vimentin in parkin-mutant fibroblasts, could contribute to impairment of cellular function, potentially contributing to the pathogenesis of Parkinson disease.
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Titolo: | Decreased amount of vimentin N-terminal truncated proteolytic products in parkin-mutant skin fibroblasts |
Autori: | |
Data di pubblicazione: | 2020 |
Rivista: | |
Handle: | http://hdl.handle.net/11586/255730 |
Appare nelle tipologie: | 1.1 Articolo in rivista |