Beta thalassemia is an hereditary autosomal recessive haematological disorder caused by defects in the synthesis of globin chains leading to reduced or absent beta (β) chains and consequently to excess of alpha (α) chains and to decrease in hemoglobin HbA (α2β2 chains <95-98%) and increase in HbA2 (α2δ2 >2-3%). Imbalance of β-globin chains in heterozygous or homozygous beta thalassemia form (Minor Thalassemia and Major Thalassemia or Cooley’s Anemia, respectively) cause haemolysis and impair erythropoiesis with a variable grade of severity. Minor Thalassemiadue to mild anemia is clinically asymptomatic and exceptionally responsible of jaundice
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Titolo: | An intruiting clinical case of Beta Thalassemia unduly taken for Thalassemia minor. |
Autori: | |
Data di pubblicazione: | 2017 |
Handle: | http://hdl.handle.net/11586/255708 |
Appare nelle tipologie: | 2.1 Contributo in volume (Capitolo o Saggio) |